摘要
骨折愈合是一个独特的多步骤过程,最终可导致正常的骨的解剖和骨的功能的恢复,而不像其他组织修复过程往往最终以瘢痕组织结束.骨折后形成大量修复性骨痂组织,包绕骨折部位.骨痂中存在两种骨形成方式:即膜内化骨和软骨内化骨.系统激素和局部生长因子参与调节骨折愈合过程中的膜内化骨、软骨形成和软骨内化骨.
The present study has determined the histological changes, VEGF （Vascular endothelial growth factor） mRNA alternative expressions and VEGF mRNA levels in ehondrogeniecallus, osteogenie-eallus and total callus by histology, RT-PCR and Northern blot during rat fracture repair. The results showed that the cellular events of intramembranous ossification, ehodrogenstrongest expressions were VEGF120 and VEGF164 mRNA. The VEGF mRNA levels in the total callus increased with time after fracture. Take together, these findings suggest that osteogenesis-derived VEGF may play a potential role to modulate the differentiation process of osteogenic and chondrogenic cells during fracture repair.
出处
《实验生物学报》
CSCD
北大核心
2005年第4期359-362,共4页
Acta Biologiae Experimentalis Sinica
