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他汀对糖尿病鼠血管内皮细胞白细胞介素-6表达的影响 被引量：2

Influence of statins on interleukin-6 expression of vascular endothelium in diabetic rats
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摘要 目的观察高血糖对大鼠动脉内皮细胞表达白细胞介素6(IL6)的影响及不同他汀药物的治疗作用。方法45只SD大鼠随机分为正常对照组9只、糖尿病对照组12只、糖尿病阿托伐他汀治疗组12只、糖尿病普伐他汀治疗组12只(用链脲佐菌素制备糖尿病模型),4周后取其主动脉,采用免疫组化检测各组大鼠动脉内皮细胞IL6的表达。结果糖尿病对照组IL6的表达量高于正常组;糖尿病两治疗组IL6的表达量均低于糖尿病对照组;两治疗组之间无显著性差异。结论高血糖促进内皮细胞产生IL6,而他汀类药物能下调血管内皮细胞IL6的表达。 Objective To investigate the effects of hyperglycemia and statin therapy on interleukin-6 expression of vascular endothelium in diabetic rats. Methods Forty-five male rats were divided randomly into control group, ST＇Z-induced diabetes group, atorvastatin treated diabetes group and pravastatin treated diabetes group. Immunohistochemical staining and computer image analysis were performed to analyze the contents and distribution of IL-6 in endothelium of aorta from four groups. Results IL-6 contents in diabetes group were significantly increased compared to that in control group; However, IL-6 contents in atorvastatin and pravastatin treated diabetes group were decreased. There was no obvious difference of IL-6 contents between atorvastatin treated diabetes group and pravastatin treated diabetes group. Conclusion Hyperglycemia can induce the product of IL-6 in vascular endothelium, statins inhibit expression of IL-6.
作者 冯波 王华 王军臣
机构地区 同济大学附属东方医院内分泌科
出处 《华中医学杂志》 CAS 2005年第4期229-230,共2页 Central China Medical Journal
关键词 糖尿病 他汀 白细胞介素-6 血管内皮细胞 糖尿病鼠 他汀药物 正常对照组 IL-6 内皮细胞表达 SD大鼠 Diabetes mellitus Statin Interleukin-6
分类号 R587.1 [医药卫生—内分泌]
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参考文献6

  • 1Devaraj S, Venugopal SK, Singh U et al. Hyperglycemia induces monocytic release of interleukin-6 via induction of protein kinase C-alpha and -beta. Diabetes, 2005, 54(1): 85.
  • 2Albert MA, Danielson E, Rifai N et al. Effect of statin therapy on C-reactive protein levels: the pravastatin inflammation/CRP evaluation (PRINCE): a randomized trial and cohort study. JAMA,2001,286(1): 64.
  • 3冯波,倪亚芳,张登海,王军臣.不同浓度葡萄糖和胰岛素对血管内皮细胞形态学影响[J].数理医药学杂志,2002,15(4):299-300. 被引量：4
  • 4Tuttle HA, Davis-Gorman G, Goldman S et al. Proinflammatory cytokines are increased in type 2 diabetic women with cardiovascular disease. J Diabetes Complications, 2004, 18(6): 343.
  • 5Srinivasan S, Hatley ME, Reilly KB et al. Modulation of PPARalpha erpression and inflammatory interleukin-6 production by chronic glucose increases monocyte/endothelial adhesion. Arterioscler Thromb Vasc Biol,2004,24(5):851.
  • 6Zhao SP, Zhang DQ. Atorvastatin reduces interleukin-6 plasma concentration and adipocyte secretion of hypercholesterolemic rabbits. Clin Chim Acta, 2003, 336(1-2): 103.

二级参考文献8

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华中医学杂志
2005年 第4期

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