短期应用胰岛素泵治疗糖尿病的临床观察

Clinical observation on short-term insulin pump infusion in treating diabetes

目的比较短期应用胰岛素泵与多次皮下注射胰岛素对控制高血糖的差异。方法178例需胰岛素治疗的高血糖住院患者,分为胰岛素泵连续皮下输注治疗组和胰岛素多次皮下注射治疗组,对比两种不同给药方法在血糖达标时间、血糖控制水平、胰岛素用量、低血糖发生率上的差异。结果泵治疗组和多次皮下注射组的血糖达标时间[(4.3±1.6)d和(11.6±3.2)d]、低血糖发生率(12.7%和41.1%)、总治疗日[(9.2±3.8)d和(12.6±4.5)d]均有统计学差异。结论短期应用胰岛素泵强化治疗能较好地模拟胰岛素分泌的生理节律,更快、更有效地控制高血糖,减少血糖的波动和低血糖的发生。

Objective To compare the difference between the short-term continuous subcutaneous insulin infusion （CSⅡ） ,and insulin multiple daily injection （MDI） in rapid control of high blood sugar. Methods 178 poorly controlled diabetic patients were randomly divided into CSⅡ group and MDI group and the differences of therapeutic time, level of blood sugar control, insulin dosage, incidence of hypoglycemia were compared in the two groups. Results Therapeutic time[ （ 4. 3 ± 1.6 ） d vs （ 11.6±3.2 ） d], incidence of hypoglycemia （ 12.7% vs41.1%） , and the period inhospital[ （ 9.2±3.8 ） d vs （12. 6 ± 4. 5 ） d]of two groups were significantly different. Conclusion The intensive treatment using short-term insulin pump infusion could imitate the physiological secretion of insulin and control glucose level.