窄谱UVB联合阿维A治疗斑块型银屑病疗效观察

Observation of the Efficacy of Narrow-band Ultraviolet B Phototherapy Combined with Acitretin on Psoriasis Plaque

目的观察311 nm窄谱中波紫外线(NB-UVB)联合阿维A治疗斑块型银屑病的疗效。方法单独采用NB-UVB照射、单独应用阿维A治疗及NB-UVB联合阿维A治疗斑块型银屑病90例,以银屑病皮损面积和严重度指数(PASI)评价疗效。结果三组在(26.16±4.37)天、(28.24±5.27)天、(18.34±3.52)天治疗后,三组治疗前后PASI评分改善率分别为(77.65±24.77)%,(78.64±23.43)%,(89.44±25.57)%;与阿维A治疗组比较,NB-UVB照射组与其疗效相当(P>0.05),而NB-UVB联合阿维A治疗组则在更短的治疗时间(P<0.05)取得了更好的疗效(P<0.05)。结论NB-UVB联合阿维A治疗斑块型银屑病疗效好,不良反应少。

Objective To observe the efficacy of narrow - band ultraviolet B（ NB - UVB） in the treatment of patients with psoriasis plaque. Methods A totat of 90 patients were treated by 311nm narrow -band ultraviolet B radiation only,acitretin only or narrow - band ultraviolet B radiation combined with acitretin. Results The efficacy was evaluated by psoriasis area and severity index （ PASI ） , After （ 26.16 ± 4.37 ） d, （ 28.24 ± 5.27 ） d and （ 18.34 ± 3.52 ） d treatment, the improved rates of PASI of NB-UVB group, aeitretin group, NB-UVB combined acitretin group were（ 77.65 ± 24.77 ） % , （ 78.64 ± 23.43 ） % and （ 89.44 ± 25.57 ） % ,respectively. When compared with acitretin group, the efficaey of NB-UVB group had no difference（ P 〉 0.05 ） ,while NB-UVB eombined acitretin group got better efficaey（ P 〈 0.05 ） in shorter time（ P 〈 0.05 ）. Conclusion Radiation of NB-UVB combined with aeitretin is safe and ean improve the efficacy significantly for psoriasis plaque.