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AmphiSox1/2/3-like基因的系统进化学分析和在文昌鱼胚胎发育中的表达

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摘要 为了研究文昌鱼胚胎发育中神经管发育的分子机制和脊椎动物中枢神经系统的起源,我们筛选和分析了与佛罗里达文昌鱼AmphiSox1/2/3基因同源的青岛文昌鱼AmphiSox1/2/3-like 基因,对其推测的氨基酸序列与17个脊椎动物和无脊椎动物的同源基因进行了系统的进化学分析,并利用胚胎整体原位杂交技术结合系列组织学切片技术,对该基因在青岛文昌鱼胚胎发育中的时空表达模式进行了系统的研究.AmphiSox1/2/3-like在原肠胚早中期开始在背部上胚层和预定神经外胚层中明显表达.在神经胚早期其表达定位于神经板.此后,表达区域位于形成中的神经管和胚胎中、后部分化中的神经管的两侧,其表达的水平从前向后逐渐下调和终止.此外,该基因在神经胚晚期和幼虫期的消化道壁中也有明显表达.研究结果显示,该基因与文昌鱼的神经分化和消化道分化密切相关.
作者 张伟 李忻怡 黄向炜 林浴霜 安云鹤 张培军 张红卫
机构地区 山东大学生命科学院发育生物学研究所 中国科学院青岛海洋研究所
出处 《自然科学进展》 北大核心 2005年第8期930-936,共7页
基金 国家自然科学基金资助项目(批准号:30070094 30270693)
关键词 AmphiSox1/2/3-like 文昌鱼 胚胎发育 进化 中枢神经系统 青岛文昌鱼 表达定位 化学分析 E基因 无脊椎动物
分类号 Q426 [生物学—神经生物学] Q959.287 [生物学—动物学]
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参考文献26

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二级参考文献17

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自然科学进展
2005年 第8期

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