摘要
目的:筛选和优化法莫替丁生物黏附片的处方。方法:采用3因素9水平的均匀设计,结合多元线性回归的方法,以溶出度为指标,对制剂处方进行筛选、优化。结果:多元线性回归结果表明,处方中生物黏附材料HPMC、卡波姆对药物释放起阻滞作用,方程较好地阐明了主要辅料对法莫替丁生物黏附片释放度的影响。结论:均匀设计优化法莫替丁生物黏附片处方结果良好,优化处方的释放速度达到设计要求。
Objective：To screen and optimize the formulation of famotidine bioadhesive tablets（FBTs）. Methods：A three- factor and ninelevel uniform design with multi- line-regression was performed to screen formulation of FBTs. The releasing behaviors of FBTs were evaluated by release test in vitro. Results：The results of regression showed that the amount of HPMC and carbomer was the main factor influencing drug release in vitro. The measuring cumulative release of FBTs fitted well the predictive cumulative release from the equation. Conclusion： It was effective and convenient to optimize the formulation of FBTs by uniform design and the drug release rate of FBTs reached the design requirements.
出处
《中国药业》
CAS
2005年第8期52-53,共2页
China Pharmaceuticals
关键词
法莫替丁
生物黏附片
均匀设计
处方筛选
famotidine
bioadhesive tablet
uniform design
formulation screening
