摘要
目的:观察联用托吡酯(TPM)治疗难治性癫痫(IE)的疗效与安全性。方法:采用开放性试验的方法,对20例IE患者进行治疗,以加用TPM前3个月的月均发作频率为基数,并与加用TPM后3个月的稳定期月均发作频率进行比较,同时观察其不良反应。结果:联用TPM治疗IE,总有效率达到75.0%,显效率为55.0%,其中3例(15.0%)完全控制;不良反应发生率为30.0%,为一过性,主要涉及中枢神经系统,其中2例出现体重减轻。结论:联用TPM对IE有良好疗效,安全性好。
Objective：To evaluate the efficacy and safety of topiramate（TPM） in treating patients with intractable epilepsy（IE）. Methods： Twenty patients with IE entered an open add- on study with TPM and were given a following- UP. The efficacy was assess by comparing the average frequency permonth of 3 months after TPM added up to maintenance period to the baseline therapy. Side effects were observed. Results：Seizure frequency reduction by ≥50% was found in 75% of all patients, and ≥75% in 55% of all patients. Three patients（15%） became seizure- free. Side effects including weight decrease, were found in 30% of patients, and the most common adverse events were related to the central nervous system, but no patients discontinued therapy, Conclusion：The topiramate is effective and safe for treating patients with IE.
出处
《中国药业》
CAS
2005年第8期73-74,共2页
China Pharmaceuticals
关键词
托吡酯
难治性癫痫
疗效
安全性
topiramate
intractable epilepsy
efficacy
safety
