小剂量艾司洛尔预防全麻拔管时的心血管反应

Cardiovascular Reaction of Small Amount of Esmolol Applied during Extubation in General Anaesthesia

目的:观察全身麻醉拔管时应用小剂量艾司洛尔时的心血管反应。方法:择期腹部手术64例患者,随机等分成两组,均用异丙酚静吸复合麻醉,拔管前5min,试验组给予盐酸艾司洛尔0.3mg/kg,30～60s内静脉注射,并记录拔管前5min(给药时),拔管前3min(给药后2min)、拔管时、拔管后1,3,5min的心率(HR)、收缩压(SBP)、舒张压(DBP)、平均动脉压(MAP),并进行统计学处理。结果:试验组在给药后各时间点的各项指标均有不同程度地降低,而对照组则明显增高,尤其在拔管时较明显(P<0.05)。结论:在全身麻醉拔出气管导管时应用小剂量艾司洛尔能有效地防止心率增快、血压升高等心血管反应。

Objective： To observe the cardiovascular reaction of small amount of esmolol applied during extubation in general anaesthesia. Methods： 64 patients with date-selected abdominal operation were divided into experiment group and control group at random, both used the compound general anaesthesia of intravenous drip and inhalation with propofol and isoflurane. The experiment group was given hydrochloric esmolol 0.3 mg/kg（30 - 60 s） before extubating. To record the data of HR, SBP, DBP, MAP at 5 min and 3 min before, during extubating and 1, 3, 5 min after extubating. These data were statisticly analysed. Results： HR, SBP, DBP, MAP of the experiment group were reduced in different degree, but those of the control group increased obviously, particularly while pulling out the tracheal tube（ P 〈 0.05）. Conclusion： Small amount of esmolol applied when extubating in the general anaesthesia can decrease cadiovascular reaction such as heart rate increasing and blood pressure raising.