Graves病患者血清细胞因子水平和甲状腺功能指标的检测分析

Study of Serum Cytokine Levels and Thyroid Function in Patients with Graves Disease

目的:探讨弥漫性毒性甲状腺肿(GravesDisease,GD)对人体血清白细胞介素-2(IL-2)、白细胞介素-8(IL-8)、肿瘤坏死因子(TNF)水平的影响。方法:采用放射免疫技术,检测135例GD患者治疗前后的IL-2、IL-8、TNF水平。结果:GD治疗前IL-2水平均低于治疗后和正常对照组,而IL-8、TNF水平在治疗后降低,且组间比较具有显著性意义(P<0.01)。对GD未治疗组血清中IL-2、IL-8、TNF与FT3、FT4、TSH进行相关性分析,结果显示IL-2与FT3、FT4呈显著负相关(P均<0.01);IL-8、TNF与FT3、FT4、TSH均无相关性(P均>0.05)。结论:IL-2、IL-8、TNF参与GD的发生与发展过程,与GD的免疫紊乱与功能状态异常间存在十分重要的内在联系。

Objective： To evaluate the influence of Graves disease on the serum levels of interleukin-2 （ IL-2）, interleukin-8 （ IL-8 ） and TNF. Method： 135 Graves patients were measured for 2 times. One was conducted before therapy as the none therapy group, the other did after therapy as the therapy group. With 36 cases as the control group, the levels of IL-2, IL-8 and TNF were tested by radioimmunoassay approach. Results： The levels of IL-2 in none therapy group is significantly lower than those of in therapy group and normal group（P〈 0.01 ）, while the levies of IL-8 and TNF in therapy group are lower than those of the other groups（P 〈 0, 01 ）. In the second place, with the analysis of none therapy group, levels of IL-2 are negatively correlated with those of FT3,FT4（P〈0.01） ,while IL-8,TNF and FT3, FT4,TSH has no correlation with each other （P 〉 0.05 ）. Conclusion： IL-2, IL-8 and TNF play important roles in the process of Graves disease and they are closely linked to the irnmunal and functional disturbance.