低分子量肝素对急性进展型脑梗死患者的疗效和血液流变性的影响

Therapeutic Effect of Low-molecular-weight Heparin on Progressive Acute Cerebral Infarction and Its Influence on Hemorheological

目的:观察低分子量肝素(LMWH)治疗治疗急性进展型脑梗死的临床疗效和对血液流变性的影响。方法:将急性进展型脑梗死患者随机分为观察组(n=42)和对照组(n=47)。均应用脱水剂、脑细胞保护剂、肠溶阿司匹林、清除自由基、防治感染、维持水电解质酸碱平衡等常规治疗。观察组在常规治疗的基础上应用LMWH5000IU腹部皮下注射,1次/天,连续7天为1疗程,治疗14天后观察临床疗效并复查血液流变学指标。结果:观察组治疗后14天的疗效明显优于对照组(P<0.01)。全血高切粘度、低切粘度、血浆粘度、纤维蛋白原等显著降低。结论:LMWH对急性进展型脑梗死具有较好疗效。

Objective： To observe the therapeutic effect of the low-molecular-weight heparin on progressive acute cerebral infarction and its influence on hemorheology. Method： Patients with progressive acute cerebral infarction were randomly divided into observation group and control group. All patients received routine treatments such as dehydrant, intestine soluble aspirin, free radical wiping agents,and maintaining balance of water and electrolyte. In observation group, the patients received injection of 5000 IU low-molecular-weight heparin daily. After 14 days treatment, clinical effectiveness and hemorheology parameters were observed. Results： The clinical effects and hemorheology improvement of patients in the observation group is much better than those in control group, Conclusion： Low-molecular-weight heparin is effective in the treatment of progressive acute cerebral infarction.