急性脑梗死凝血酶抗凝血酶Ⅲ复合物的研究

Change of thrombin antithrombin Ⅲ complex after acute brain infarction

目的研究急性脑梗死患者凝血系统的变化。方法测定57例急性脑梗死患者入院时、入院后1d、3d、7d的凝血酶时间(TT)、凝血酶原时间(PT)、活化的部分凝血活酶时间(APTT)、纤维蛋白原(FIB)含量的变化,其中21例同时检测血浆凝血酶抗凝血酶Ⅲ复合物(thrombinantithrombinIIIcomplex,TAT)。并与正常健康对照19名进行比较。结果急性脑梗死患者TAT升高(P<0.05),2例进展性卒中患者TAT明显增高(P<0.01)。急性脑梗死患者TT、PT、APTT无明显动态变化(P>0.05),FIB含量入院后7d高于治疗前(P<0.05)。结论普通凝血指标不能显示急性脑梗死患者的高凝状态。TAT明显增高对进展性卒中早期诊断有意义。

Objective To determine the change of coagulation in acute brain infarction. Methods Blood samples were taken intravenously from 57 patients with acute brain infarctions （within 24hr） and the thromhin time（TT）, prothrombin time（PT）, activated partial thromhoplastin time（APTT）, fibrinogen（FIB） levels were detected serially at the time of instant admission, 1st day ,3rd day and 7th day after routine therapy, including 21 patients whose thrombin antithrombin Ⅲ complex（TAT） levels were detected at the same time. Results TAT levels were significant increased in acute brain infarctions, especially in acute progress stroke, but TT, PT, APTT were not significantly different before and after routine treatment. FIB levels were higher at 7th day than pre-treatment. Conclusion TAT levels can be served as a marker of progress stroke.