伴有中央颞区棘波的良性癫痫患儿认知功能事件相关电位研究

Cognitive function impairment in children with benign epilepsy with centro-temporal spikes:an event-related potential study

目的研究伴有中央颞区棘波的儿童良性癫痫(BCECTS)患儿是否存在认知功能损害以及探讨评价认知功能损害的的敏感指标。方法21例BCECTS儿童作为患者组,与其年龄、性别、受教育程度及家庭社会经济状况匹配的健康对照21名。成对的个位数字(S1和S2)依次呈现,要求受试者判断两个数字相同或不同。同步记录事件相关电位。结果两组在两个数字数值不同时都可以诱发出冲突负波N270。患者组N270的峰潜伏期均较对照组延长,波幅下降,而患者组P300的潜伏期及波幅与对照组无显著性差异。结论BCECTS儿童存在认知功能的损害。N270在评价轻度认知功能损害方面,敏感性高于P300。

Objective To find the cognitive function impairment in children with benign epilepsy with centro-temporal spikes and to find a sensitive index which can reveal the cognitive function impairment. Methods 21 patients with benign epilepsy with centro-temporal spikes participated in this study. 21 normal subjects, matched for age, gender, years of education and family socioeconomic status, served as controls. Subjects were asked to judged weather the two sequentially presented numbers （S1 and S2） in a digit pair were identical or not, while event-related potential （ERPs） were recorded from electrodes on their scalp. Results N270 was evoked by S2 of the conflict condition in either controls or patients. Compared with control group, N270 latency was significantly prolonged and the amplitude decreased in the patient group. However, the peak latency and amplitude of P300 were not changed significantly in patient group. Conclusion Children with benign epilepsy with centro-temporal spikes as a group show cognitive function impairment. Conflict negative N270 can be employed as a method for evaluating cognitive disturbance, which seems subtler than P300 in detecting mild cognitive function impairment.