比索洛尔和美托洛尔的降压疗效及安全性对比

Comparison of therapeutic efficacy and safety between bisoprolol and metoprolol in treating hypertension

目的:对比观察国产比索洛尔(博苏)和美托洛尔(倍他洛克)治疗轻、中度高血压患者的临床疗效与安全性。方法:46例轻、中度高血压患者随机分成比索洛尔和美托洛尔两组,分别每日口服1次比索洛尔及2次美托洛尔,治疗8周,并用24小时动态血压监测评价用药前及用药8周后24小时血压变化情况。结果:服药第8周降压总有效率比索洛尔组91. 3%,美托洛尔组73. 9%,与用药前相比两组治疗后的收缩压及舒张压均显著降低,但比索洛尔组优于美托洛尔组(P<0. 05) ,且副作用少(P<0. 01) ,对血脂、血糖无影响。结论:国产比索洛尔降低轻、中度高血压患者的血压,安全有效,并优于美托洛尔。

Objective： To contrast the therapeutic efficacy and safety of bisoprolol and metoprolol in treating low-grade and moderate-grade hypertension. Methods： A total of 46 patients with low-grade and moderate-grade hypertension were admitted. They were randomly averagely divided into bisoprolol group and metoprolol group ,only taken bisoprolol once or metoprolol twice each day respectively. The therapeutic efficacy and safety of two groups were compared on reducing blood pressure evaluated by ABPM after 8 weeks. Results ： The total efficacy rate of bisoprolol and metoprolol was 91.3% and 73.9% respectively （P〈0.05）. The side-effect of bisoprolol （13.1%） was lower than that of metoprolol （21.7%, P〈0.01）. No side-effects for blood glucose and lipid were found for two groups. Conclusion：Bisoprolol can effectively reduces blood pressure and does not effecting blood glucose and lipid in patients with lowgrade and moderate-grade hypertension.