云木香化学成分研究

The chemical constituents from Saussurea lappa C.B Clarke

目的研究中药云木香的化学成分.方法利用硅胶、大孔树脂、Sephadex LH-20柱色谱及HPLC等方法进行分离纯化,根据理化性质和波谱数据进行结构鉴定.结果得到8个化合物,分别鉴定为脱氢木香内酯(1)、木香烯内酯(2)、arbusculin A(3)、白桦脂醇(4)、5-羟甲基糠醛(5)、3,5-二甲氧基-4-羟基苯甲醛(6)、正丁基-β-D-吡喃果糖苷(7)、油酸-1-甘油单酯(8).结论化合物5～8为首次从该植物中分得.

Aim To study the chemical constituents of Saussurea lappa C. Methods The compounds were isolated by column chromatography on silica gel, Diaion 101, Sephadex LH-20, and HPLC. Their structures were determined on the basis of physicochemical properties and spectroscopic evidence. Results Eight compounds were identified as dehydrocostus lactone（1）, costunolide（2）, arbusculin A（3）, betulin（4）, 5-hydroxymethyl- furaldehyde（ 5 ）, 3, 5-dimethoxy-4-hydroxybenzaldehyde （ 6 ）, n -butyl-β-D- fructopyranoside （ 7 ）, 9,12-octadecadienoic acid（Z, Z）-2, 3-dihydroxypropyl ester（8）, respectively. Conclusion Compounds 5, 6, 7 and 8 are obtained from this plant for the first time.