1Krieg AM, Yi AK, Matson S, et al. CpG motifs in bacterial DNA trigger direct B - cell activation[ J]. Nature, 1995,374(6522) :546 - 549.
2Krieg AM, Hartmann G, Yi AK, et al. Mechanism of action of CpG DNA[J]. Curr Top Microbiol Immunol,2000,247( 1 ): 1 - 21.
3Bird AP. CpG- rich islands and the function of DNA methylation[J] .Nature, 1986,321(6067) :209 - 213.
4Rankin R, Pontarollo R, Ioannou X, et al. Identification of a stimulatory CpG motif for veterinary and laboratory species demonstrates that sequence rec ognition is highly conserved[J]. Antisense and Nucleic Acid Drug development,2001,11(5) :333 - 340.
5Wernette CM, Smith BF, Barksdale ZL, et al. CpG oligodeoxynudeotides stimulate canine and feline immune cell proliferation[J]. Vet Immunol Immunopathol, 2002, 84(3 - 4) :223 - 236.
7Jiang W, ederman M L, Salkowitz J, et al. Impaired monocyte maturation in response to CpG oligodeoxynucleotide is related to viral RNA levels in HIV dis ease and is at least partially mediated by deficiencies in type Ⅰ interferon respon siveness and production[ C ]. 12th conference on retroviruses and opportumistic infections USA.2005,2,22- 25.
8Muzio M, Feng P, Dixit VM. IRAK (Pelle) family member IRAK - 2 and MyD88 as proximal mediators of IL - 1 signaling [ J ]. Science, 1997, 278(5343): 1612 - 1615.
9Medzhitov R, et al. MyD88 is an adaptor protein in the hToll/IL- 1 receptor family signaling pathways[J]. Mol. Cell, 1998,2(2) :253 - 258.
10Takeshita F, Leffer C A, Gursel I, et al. Cutting edge: role of Toll - like receptor 9 in CpG DNA - induced activation of human cells [ J ]. Immunol,2001,167 (7) :3555 - 3558.
二级参考文献66
1KRIEG A M,YI A K, KLINMKN D M. CpG motifs in bacterial DNA trigger direct B-cell activation [ J]. Nature, 1995,374:546 - 549.
2KLINMAN D M, YI A K, BEAUCAGE S L, et al. CpG motifs present in bacterial DNA rapidly induce 1.vmplaocytes to secrete interleukin 6, interleukin 12, and interferon r[ J]. Proc Nail Acad Sci USA,1996,13:2 879 - 2 883.
3KLINMAN D M, YAMSHCHIKOV G, ISHIGATSUBO Y.Contribution of CpG motifs to the immunogenicity of DNA vaccines[J]. J Immunol, 1997,158(8) :3 635 - 3 655.
4TOKUNAGA T, YAMAMO'ID H, SIIIMAD A S, et al. Antitumor activity of deoxyribonucleic acid fraction from mycobacterium bovis BCG isolation, physicochemical characterization, and antitumor activity[J]. J Nail Cancer Inst,1984,72:955 - 962.
5CHU I1 S, TAItGONq O S, KRIEG A M, et al. CpG oligodeoxynucleotides as adjuvants that switch on T helper 1(Thl) immunity[J]. J Exp Med, 1997, 186(10): 1 623-1 631.
6Krieg A M,Yi A K,Klinman D M.CpG motifs in bacterial DNA trigger direct B-cell activation[J].Nature,1995,(374):546-549.
7Klinman D M,Yi A K,Beaucage S L,et al.CpG motifs present in bacterial DNA rapidly induce lymphocytes to secrete interleukin 6,interleukin 12,and interferonr[J].Proc Natl Acad Sci USA,1996,(13):2 879-2 883.
8Klinman D M,Yamshchikov G,Ishigatsubo Y.Contribution of CpG motifs to the immunogenicity of DNA vaccines[J].J Immunol,1997,158(8):3 635-3 655.
9Sato Y,Roman M,Tighe H,et al.Immunostimulatory DNA se quences necessary for effective imtradermal gene immunizatio[J].Science,1996,(273):352-354.
10Tokunage T,Yamamoto H,Shimad A S,et al.Antitumor activity of deoxyribonucleic acid fraction from mycobacterium bovis BCG Isolation,physicochemical characterization,and antitumor activity[J].J Natl Cancer Inst,1984,(72):955-962.