TORCH感染与新生儿及婴儿肝炎综合征的关系

Relationship between TORCH Infection and Neonatal and Infantile Hepatitis Syndrome

目的探讨TORCH感染在新生儿、婴儿肝炎综合征发病中的作用.方法应用ELISA法对新生儿婴儿肝炎综合征97例患儿进行血清TORCH-IgM抗体测定.对CMV感染患儿除采用常规综合治疗外,加用更昔洛韦10 mg/(kg·d)静脉滴注,12 h/次,连用12～20 d.结果新生儿中21例、婴儿中16例患TORCH感染,均以巨细胞病毒感染为最多;母婴配对7例TORCH感染;对17例巨细胞病毒感染用更昔洛韦治疗,9例抗体转阴.结论 TORCH感染是新生儿、婴儿肝炎综合征主要原因之一,TORCH感染引起临床表现多样化,更昔洛韦是治疗巨细胞病毒感染的有效药物.

Objective To study the attack of TORCH infections in neonatal and infantile hepatitis syndrome. Methods TORCH-IgM antibody in serum was measured by enzyme-linked immunosorbent assay（ELISA）. Seventeen patients with CMV infection were given ganciclovir[ 10 mg/（kg·d）] ,once every 12 hours. Results Twenty-one newborns and 16 infants were infected with TORCH.Most cases of newborns and infants concerned were infected by cytomegalovirus; Seven patients in pairs of mothers and infants were infected with TORCH. The antibody on 9 out of 17 patients with cytomegalovirus infection had converted to negative after the treatment with ganciclovir. Conclusions TORCH infection is one of the main causes of the neonatal and infantile hepatitis syndrome. TORCH infection leads to different clinical manifestations,and ganciclovir is one effective drug for treating cytomegalovirus infection.