产超广谱β-内酰胺酶细菌感染患儿免疫功能情况

Study on Immune Function of Children Infected by Bacteria Excreting Extended Spe ctrum β-Lactamases

目的研究与超广谱β-内酰胺酶(ESBLs)阳性菌感染与免疫因素的关系。方法对49例入院时查ESBLs阴性菌感染、住院期间查ESBLs转为阳性的患儿进行免疫功能检查,与60例同期同年龄组ESBLs阴性菌感染患儿免疫功能相比较;检查免疫功能低下患儿ESBLs阳转率,与免疫功能正常患儿比较。结果ESBLs阳转49例免疫功能低下(P<0.01),恢复期免疫功能改善。免疫功能低下患儿ESBLs阳转率高于免疫功能正常患儿。结论免疫功能低下是ESBLs的易感因素。抗菌治疗同时加强免疫支持常可减少ESBLs菌阳转可能,缩短住院时间。

Objective To observe the relationship between extended spectrumβ-lactumases（ESBLs） bacteria infection and immune factor in children. Methods Immune function were tested in 49 children with ESBLs infection,that the test of ESBLs changed from negative to positive in hospital and compared with that of ESBLs bacteria negative infected case, children with hypoimmunity and normal immune function. Results Forty-nine cases of ESBLs bacteria posituve-changed children had lower imune function and their immune function improved when restored. The rate of ESBLs positive changed was significant higher in hypoinmmnity than thatof normals（P〈 0.01 ）. Conclusion Hypoimmnnity is a susceptibility factor of ESBLs bacteria infection, Immunotherapy can decrease the positive changed rate and do good to health.