重复注射A型肉毒毒素治疗痉挛型脑性瘫痪

Effect of Local Intramuscular Repeated Injection with Botulinum Toxin-A for Treatment of Spastic Cerebral Palsy

目的观察重复肌肉注射A型肉毒毒素(BTX-A)治疗痉挛型脑性瘫痪的疗效。方法用BTX-A对30例重度痉挛型脑性瘫痪患儿进行2次局部肌肉注射,2次注射间隔为3个月,注射剂量4 U/(kg.次)。以改良阿氏量表(MAS)评定肌张力,以运动评价量表(PRS)评定运动功能。分析注射前、2次重复注射后3个月的肌张力、PRS分数变化。应用配对t检验进行统计分析。结果BTX-A第2次治疗前后肌张力、PRS分值均具有显著性差异(P均<0.001)。结论局部重复肌肉注射BTX-A能有效治疗重度痉挛型脑性瘫痪,提高运动功能。

Objective To observe the curative effect of botulinum toxin A（BTX -A）repeated intramuscular injection for treatment of ,serious spastic cerebral palsy. Methods Thirty eases with ,serious spastic cerebral palsy received local repeated intramuscular injection. The interval time was 3 months. The dose of BTX-A was 4 U/kg. The muscle tone was assessed with the modified ashworth scale and range of motion with physical rating scale（PRS）. The indexes were evaluated before injection and 3 months after the second injection. Paired-samples t-test was used in the statistic analysis. Result The muscle tone and PRS had renmrkable improvement after second therapy with BTX-A（P〈0.001）. Conclusion Local repeated intramuscular injection with BTX-A can effectively treat serious spastic cerebral palsy.