人类巨细胞病毒与宫颈癌关系初探

PRELIMINARY STUDY ON THE RELATIONSHIP BETWEEN HUMAN CYTOMECGALOVIRUS AND CERVICAL CANCER

本文报告了用补体结合(CFT)和免疫酶组化法(IPA)检测宫颈癌低发区(A组)和高发区(B组)健康妇女及临床诊断为宫颈糜烂(C组)和宫颈癌(D组)患者共150份血清中的HCMV—IgG和IgM抗体。结果表明:A组的HCMV—IgG显著低于其它三组(P<0.001),其它三组之间无显著差异(P>0.05);A组的HCMV—IgM与B组之间差异显著(P<0.005),B组与D组之间亦有非常显著的差异(P<0.002)。CFT抗体的几何平均滴度依次为8.88、30.82、42.71和50.51。上述结果提示:HCMV感染与宫颈癌的发生有一定的关系,为研究宫颈癌的病毒病因提供了初步实验依据。

IgG and IgM antibodies to human cytomegalovirus (HCMV) in 150 sera were detected by complement fixation test (CFT) and immunoperoxidase assay (IPA). Sera were collected from four groups, namely healthy women in the area of low (group A) and high (group B) incidence of cervical cancer, the patient diagnosed as cervical erosion (group C ) and cervical cancer (group D). The results showed that HCMy-IgG titer of group A was significantly lower than those of group B,C and D (P<0.001), no significant difference was found among group B, C and D (P>0.05).There was significant difference between HCMV-IgM in group A and B (P<0.005), and also between group B and D(P< 0.002). The geometric mean titers of CFT-antibody of group A,B,C and D were 8.88, 30.28, 42.71 and 50. 10. respectively . The results suggested that cervical cancer is related to HCMV infection and provided a tentative basis for study on the pathogenesis of cervical cancer.