电针对禁食犬心肌代谢影响的初步观察

PRELIMITARY OBSERVATION ON EFFECT OF ELECTROACUPUNCTURE ON MYOCARDIAL METABOLISM IN FASTING DOGS

晚近的心脏生理学研究表明,心脏为维持血液循环,一昼夜搏血达8吨之多,同时消耗大量的能量。其能量主要来源于冠状动脉提供的氧和代谢底物在心肌线粒体中的氧化磷酸化过程。由于心肌耗能多,使其氧储和高能磷酸键的储量均较少,因此其对能、氧缺乏十分敏感。许多研究表明,电针可以改善缺血和缺氧状态下的心脏功能,然而电针对禁食状态下心脏的影响尚未见报导,本工作主要观察了电针对禁食犬心肌游离脂肪酸摄取,心肌葡萄糖摄取及心肌氧耗量的影响。材料与方法实验对象:28只健康杂种犬被随机分为对照组和电针组,每组14只。

(?) was observed in the study that effect of electroacupuncture (EA) on energy and oxygen metabolism of myocardium in fasting dogs.28 healthy mongrel dogs were divided into control and electroacupuncture (EA) group randomly.All the dogs were used in the experiment after fast of 7 days,and during the fasting the dogs were fed with water.The result shows that before EA,the quantity of myocardial uptake of free fatty acid (FFA) and glucose and m(?)ocardial consumption of oxygen in control group have not marked difference from that in EA group respectively (P>0.05). Myocardia uptake of FFA in EA group was obviously decreased than that in control group after EA on Pishu and Zhongwan points (P<0.05) and myocardial uptake of glucose in EA group was (?)nhanccd in comparson with that in control group (P<0.05).After removing needles,myocardial upeake of FFA was reduced in contrast to that before EA in EA group with statistical significance (P<0.05).Myocardial consumption of oxygen showed a depr- essing tendency after EA in EA group.but after removing needles,the data of myocardial consumption of oxygen had no difference from that before EA in EA group (P>0.05) and there was not different too in comparison of all the corresponding data between the EA and contral group separately. The result shows that the state of myocardial metabolism in fasting dogs could be improved by EA such as myocardial uptake of glucose was enhanced and myocardial uptake of FFA was reduced. It is possible that this result is due to reduction of the depressing affect of FFA metabolism to glucose metabolism in myocardium by EA.