隔核参与针刺镇痛的传入途径

THE AFFERENT PATHWAY OF THE SEPTAL NUCLEI ON PARTICIPATION IN ACUPUNCTURE ANALGESIS

隔核包括内侧隔核(sin)、外侧隔核(sl)、斜角带核(td),三角隔核及伞隔核等。sm、sl 及 td 是其主要部分。隔核是边缘前脑的重要结构,含有大量的胆碱能细胞、密集的脑啡肽能神经未梢和细胞体以及丰富的阿片受体,与痛觉机能有密切的关系。电刺激隔区能使动物的痛阈升高以及能提高电刺激牙髓的阈值;刺激隔区对外侧核、束旁核、中缝背核及中脑导水管周围灰质的痛诱发电位有明显的抑制作用。说明隔区参与痛觉的调节。对隔区已有许多形态学研究,但对隔区亚细胞群与脑内某些与疼痛有关区域的联系尚未见专门报道。我们采用 HRP、WGA-HRP 和 CB-HRP 法较详细地观察了与疼痛有关脑区至隔区主要亚细胞群 sm、sl、td 的传入联系。材料和方法实验用成年大鼠133只,选其中定位较准确,较局限的45只作为分析材料。

The afferent connections of septal nuclei from the brain areas relating to pain in the rat were studicd with HRP,WGA-HRP and CB-HRP methods. Some brain areas relating to pain,for instance,locus coeruleus,raphe nuclei,periaqueductal gray,hypothalamus,lateral habenular nucleus,amygdaloid complex,hippocampus and cingulate cortex,project to medial septal nucleus,lateral nucleus and diagonal band nucleus. The many areas relating to acupuncture analgesis project to septal nuclei,it is possible that the septal nuclei participate in regulating pain in the central nervous system.