血压变化与肝硬化患者生存时间的关系研讨

Relationship between the Change in Blood Pressure in Cirrhotic Patients and Their Prognosis

目的探讨肝硬化患者外周血压变化情况及其与预后的关系。方法按照Child-Pugh分级,将149例肝硬化患者分成Ⅰ、Ⅱ和Ⅲ组,其中A级(Ⅰ组)45例、B级(Ⅱ组)49例、C级(Ⅲ组)55例。比较各组的血压差异。并进行随访血压与生存时间的关系。结果Ⅰ组平均血压为(129.2±8.6)/(76.3±6.6)m m H g;Ⅱ组为(118.1±8.6)/(71.8±5.3)m m H g;Ⅲ组为(101.3±9.1)/(64.2±5.5)m m H g。提示患者血压随Child-Pugh分级增加而下降(P<0.05)。随访发现,外周血压低的患者生存时间更短。结论患者的外周血压直接与肝功能好坏有关。外周血压降低提示患者的预后不佳。

Objective To investigate the relationship between the change in blood pressure in cirrhotic patients and their prognosis. Methods A total of 169 cirrhotic patients were divided into 3 groups （Ⅰ, Ⅱ and Ⅲ） according to Child-Pugh grade. The blood pressure of each group was compared. And the relationship between blood pressure and survival time was analyzed through long-term foUow-up. Results The blood pressure of group Ⅰ, Ⅱ, and Ⅲ were （129.2 ±8.6）/（76.3 ±6.6）mmHg, （ 118.1 ±8.6）/（71.8 ±5.3）mmHg and （ 101.3 ±9.1）/（64.2 ±5.5）mmHg, respectively. There was a remarkably decrease in blood pressure from A grade to C grade. Moreover, the individual with hypotension has a shorter survival time than others. Conclusion The blood pressure of cirrhotic patients may has a direct association with liver function and is a biomarker to predict their good or bad prognosis.