阿托伐他汀联合低分子肝素钙对高脂血症并高凝状态干预的研究

Evaluation of efficacy of atovastatin and low molecular weight heparin in the treatment of hyperlipidemia and hypercoagulation state

目的观察阿托伐他汀及低分子肝素钙对高脂血症并高凝状态的疗效。方法对46例高脂血症合并血液高凝状态患者在常规治疗基础上加用阿托伐他汀及低分子肝素钙治疗,比较治疗前后血脂各项指标及凝血功能(TT、PT、APTT、FIB)、D二聚体(D-D)及血小板(PLT)变化。结果治疗前后血脂各项指标有明显改变,降低总胆固醇的总有效率达95.6%,降低甘油三酯的总有效率为84.8%,且治疗后FIB、D-D明显降低,TT、PT、APTT及PLT无明显变化。结论阿托伐他汀及低分子肝素钙对高脂血症并高凝状态有较好的疗效,能有效降低血脂(总胆固醇和甘油三酯),改善血液高凝状态,副作用较少,是目前治疗高脂血症并高凝状态较好的方法。

Objective To evaluate the effect of atovastatin and low molecular weight heparin（LMWH） on hyperlipidemia and hyercoagulation state. Methods 46 patients with hyperlipidemia and hypercoagulation state were treated with atovastatin and LMWH base on the routine therapy. The changes of total cholesterol（TC）, triglyceride（ TG）, thrombin time（TT）, prothrombin time（PT）, activated partial thrombin time（APTT）, fibrinogen（FIB）, D-dimer（D-D） and platelet（PLT） were compared before and after treatment. Results TC decreased by 95.6% ,TG decreased by 84.8% ,and FIB was reduced significantly. But there was no significant change in TT, PT, APTT or PLT. Conclusion Atovastatin and LMWH are more effective and less side effect in the treatment of hyperlipidemia and hyercoagulation state.