视网膜神经节细胞非经典感受野及其方位倾向性的模型研究

Modeling of the Non-classical Receptive Field and the Orientation Bias of Retinal Ganglion Cells

建立了包含无长突细胞相互抑制网络的视网膜神经节细胞的三层网络模型,以验证李朝义等提出的非经典感受野可能源于无长突细胞相互抑制的假说,并探讨神经节细胞感受野的方位倾向性的可能机制.模拟结果表明,通过无长突细胞之间的相互抑制可以形成神经节细胞的非经典感受野.模型模拟了神经节细胞的中心区和大周边区的方位倾向性及其相互作用,结果提示神经节细胞的方位倾向性可能主要源于神经节细胞树突野的空间分布.

To test the assumption that the extended surround of the non-classical receptive field of retinal ganglion cells might he formed from the mutual inhibition among the amacrine cells,and to explore the possible mechanism underlying the orientation bias,a three-layer model of the non-classical receptive field of retinal ganglion cells was constructed. Both area responses and orientation bias were simulated. Results hint that mutual inhibition among the amacrine cells plays a key role in the formation of extended surround in the non-classical receptive field of the retinal ganglion cell, and the orientation bias may mainly be decided by the elliptic shape of the dendrite field of the ganglion cell, while the shape of the dendrite field of amacrine cell has little influence.