小儿肠胃康颗粒主要药理学研究

Pharmacodynamics studies on Xiaoer Changweikang granules

目的研究小儿肠胃康颗粒的主要药理作用,为临床应用提供参考。方法研究小儿肠胃康颗粒对小鼠胃排空和小肠推进的作用及对大鼠胃液分泌的作用,考察其对胃肠功能的影响;通过急性炎症模型考察其抗炎作用。结果小儿肠胃康颗粒12,24g(生药)·kg-1灌胃给药可以明显促进小鼠胃排空和小肠推进(P<0.05或0.01);4.8,9.6,19.2g(生药)·kg-1可以增加大鼠胃液量和胃蛋白酶活性,降低胃液pH;24g(生药)·kg-1可以抑制二甲苯致小鼠耳肿胀,降低醋酸引起的小鼠腹腔通透性升高(P<0.05)。结论小儿肠胃康颗粒能提高胃肠道功能并有抗炎作用。

OBJECTIVE To study the pharmacological effect of Xiaoerchangweikang granules for providing some data for its clinical use. METHOD The effects of Xiaoerchangweikang granules on the function of stomach empty and small intestine push in mice and the secretion of gastric juice in rats were studied. Acute inflammation model was used to investigate its antiinflammation. RESULTS Xiaoerchangweikang granules could accelerate the stomach empty and small intestine push in mice in the doses of 12,24g·kg^-1 intragastrically and increase the secretion of gastric juice, the activity of pepsin, decrease the value of pH in rats taken by duodenum （ P 〈 0.05 or P 〈 0.01 ）. Meanwhile, the edema of ear induced by xylene and the permeability caused by acetic acid were inhibited by Xiaoerchangweikang granules. CONCLUTION Xiaoerchangweikang granules can improve the function of stomach and intestine and shows the effect of antiinflammation.