动态比浊法定量检测硝酸异山梨酯注射液中的细菌内毒素

Determination of bacterial endotoxin in isosorbide dinitrate injection by kinetic turbidimetric assay

目的建立硝酸异山梨酯注射液细菌内毒素定量分析方法。方法采用动态比浊法,对硝酸异山梨酯注射液稀释液进行定量检测。结果硝酸异山梨酯注射液无干扰作用。结论可以进行定量检测。

OBJECTIVE To establish the method for the test of bacterial endotoxia in isosorbide dinitrate injection. METHODS The kinetic turbidimetric assay was used. RESULTS This test showed that tachyplens amebocyte lysate was not disturbed by isosorbide dinitrate injection. CONCLUSION The kinetic turbidimetric method can be used for determination of bacterial endotoxin in isosorbide dinitrate injection.