吗啡对猕猴腹侧前额叶脑电γ振荡的影响

Effect of Morphine on γ-band of EEG Activity in the Orbital Frontal Cortex of Rhesus Monkey

为了从神经电生理的角度提供吗啡对腹侧前额叶脑功能影响的证据,通过电生理记录分析技术获取了肌肉注射吗啡(0、0.5、1.6、5.0和8.0mg/kg)后,猕猴腹侧前额叶皮质脑电γ振荡活动的动态变化。结果发现:吗啡导致腹侧前额叶脑电γ振荡功率下降,而且这种影响具有明显的负性量效关系。以上结果说明腹侧前额叶的γ振荡活动与吗啡摄入有密切的关系,并提示脑电γ振荡活动也许可以反映吗啡成瘾的情况。

Previous studies have shown that the ventral part of prefrontal cortex （vPFC） plays an important role in drug addiction. The increased interest in γ oscillations, now widely regarded as functionally relevant signals of the brain, underlines the importance of the concept of event-related oscillations for bridging the gap between single neurons and neural assemblies. In the present study, we examined the dynamics of γ oscillation activity （or γ-band power） associated with the development of morphine dependence in the vPFC by using electrophysiological techniques after injecting morphine （0, 0.5, 1.6, 5.0 and 8.0 mg/kg） in rhesus monkeys. The results show that the γ-band power had a long-term decrease associated with the development of morphine dependence, and the decrease in γpower had a negative relationship with the concentration of morphine. Those results suggest strongly that γ oscillation activities in the vPFC reflect morphine addiction, and indicate that the EEG γ oscillation may reflect the processes underlying morphine addiction.