中青年突发性聋患者与全身性低血压的相关性研究

Observation of the relationship between systemic hypotension and sudden sensorineural deafness in young subjects

目的综合评估中青年突发性聋(SSHL)患者与全身低血压的关系。方法选择28例确诊为SSHL未经治疗的中青年(50岁以下)患者为实验组,均行听力学、即时血压、心率、24h动态血压连续监测、脂质代谢参数等检查。同时选择30例年龄、性别相匹配的正常血压非SSHL者为对照组进行同等处理。结果实验组平均的即时和动态血压(SBP、DBP)都显著低于对照组。两组在心血管疾病高危因子的统计差异不显著。实验组的低血压患病率显著高于对照组。结论全身性低血压的存在可引起耳蜗微循环的低灌注,而耳蜗缺血很可能是中青年SSHL患者的发病机制之一,尤其是耳蜗末梢顶转的血供会直接影响到低频听力。对此类患者的血压动态监测和限制使用血管扩张药是很有必要的。

Objective：To confirm whether systemic hypotension influences the genesis of sudden sensorineural deafaess（SSD） in young people. Method=Twenty-eight untreated young patients diagnosed as SSD in experimental group were compared with 30 age- and sex- matched subjects in control group. Both groups have received the clinic BP testing, 24 hour BP monitoring and their indexes about lipid metablism were examined and recorded. The statistical analysis was carried out on the data obtained from 2 groups. Result： The average clinic and 24 hour BP values in patients with SSD were significantly lower. The hypotension （diagnosed according to ISD standard） occured more frequently in SSD group. There was no difference in metabolism indexes between 2 groups. Conclusion： Systemic hypotension which can cause perfusion damage in cochlea can be considered as a possible cause responsible for the development of SSD in young subjects. It＇s necessary to keep blood pressure monitoring and avoid applying vasodilating drugs until a suspecting or known hypotensive condition is associated with hearing loss.