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转基因技术在器官移植中的应用 被引量：1

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作者 余洪华 陆晓和 张永强
机构地区 南方医科大学珠江医院眼科
出处 《广东医学》 CAS CSCD 北大核心 2005年第9期1291-1292,共2页 Guangdong Medical Journal
基金 广东省自然科学基金资助项目(编号:04020438)
关键词 转基因技术 器官移植 靶细胞 急性排斥反应 免疫抑制药
分类号 R617 [医药卫生—外科学] Q789 [生物学—分子生物学]
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参考文献16

  • 1Guillot C, Mauff B, Cuturi MC, et al. Gene therapy in transplantation in the year 2000:moving towards clinical applications? Gene Ther,2000,7(1):14.
  • 2Mathieu P, Chauveau C, Bouchet D, et al. Genetic engineering in allotransplantation of vascularized organs. Gurr Gene Ther,2002,2(1):9.
  • 3Thomas CE, Ehrhardt A, Kay MA. Progress and problems with the use of viral vectors for gene therapy. Nature Rev Genet,2003,4(5) :346.
  • 4Guillot C,MathieuP, Coathalem H,et al. Tolerance to cardiac allografts via local and systemic mechanisms after adenovirus - mediated CTLA4Ig expression. J Immunol,2000,164(10) :5258.
  • 5Guillot C, Guillonneau C, Mathieu P, et al. Prolonged blockade of CD40-CD40L interactions by gene transfer of CD40Ig results in long - term heart allogaft survival and donor- specific hyporesponsiveness but does not prevent chronic rejection. J Immuno,2002,168(4):1600.
  • 6Min WP, Gorczynski R, Huang XY, et al. Dendritic cells genetically engineered to express Fas ligand induce donor - specific hyporesponsivenessand prolong allograft survial. J Immunol,2000,164(1): 161.
  • 7David A, Chetritt J, Heslan J M, et al. Prolongation of rat cardiac allograft induced by adenovirus - mediated pene transfer of IL - 10. Gene Ther,2000,7(6):505.
  • 8Josien R, Douillard P, Guillot C, et al. A critical role for transforming growth factor- [beta](TGF- [beta])in donor transfusion- induced allograft tolerance. J Cliin Invest,1998,102(11):1920.
  • 9Barrou B, Bertry-CoussotL, Morin S,et al. Prolonged islet allograft survival by adenovirus - mediated transfer of sICAM - 1/Ig immunoadhesin gene. Hum Gene Ther, 2002,13(12):1441.
  • 10DeBruyne LA, Li K, Bishop DK, et al. Gene transfer of virally encoded chemokine antagonists vMIP- Ⅱ and MC148 prolongs cardiac allograt survival and inhibits donor- specific immunity. Gene Ther,2002,7(7) :575.

同被引文献19

  • 1KLEBE S,COSTER D J,SYKES P J,et al.Prolongation of sheep corneal allograft survival by transfer of the gene encoding ovine IL-12-p40 but not IL-4 to donor corneal endothelium[J].J Immunol,2005,175(4):2219-2226.
  • 2RAYNERS A,LARKIN D F,GEORGE A J.TNF receptor secretion after ex vivo adenoviral gene transfer to cornea and effect on in vivo graft survival[J].Invest Ophthalmol Vis Sci,2001,42(7):1568-1573.
  • 3SWENSON K M,KE B,WANG T,et al.Fas ligand gene transfer to renal allografts in rats[J].Transplantation,1998,65(2):155-160.
  • 4SANO Y,SOTOZONO C.Role of Fas ligand in ocular tissue[J].Cornea,2002,21(Suppl):S30-32.
  • 5OSAWA H,MARUYAMA K,STREILEIN J W.CD95 ligand expression on corneal epithelium and endothelium influences the fates of orthotopic and heterotopic corneal allografts in mice[J].Invest Ophthalmol Vis Sci,2004,45(6):1908-1915.
  • 6STUART P M,YIN X,PLAMBECK S,et al.The role of Fas ligand as an effector molecule in corneal graft rejection[J].Eur J Immunol,2005,35(9):2591-2597.
  • 7WILLIAMS K A,STANDFIELD S D,SMITH J R,et al.Corneal graft rejection occurs despite Fas ligand expression and apoptosis of infiltrating cels[J].Br J Ophthalmol,2005,89(5):632-638.
  • 8SANO Y,YAMADA J,ISHINO Y,et al.Non-cleavable mutant Fas ligand transfection of donor cornea abrogates ocular immune privilege[J].Exp Eye Res,2002,75(4):475-483.
  • 9WILLIAMS K A,JESSUP C F,COSTER D J.Gene thetapy approaches to prolonging corneal allograft survival[J].Expert Opin Biol Ther,2004,4(7):1059-1071.
  • 10LEVISETTI M G,PADRID P A,SZOT G L,et al.Immunosuppressive effects of human CTLA4-Ig in a non-human primate model of allogeneic pancreatic islet transplantation[J].J Immunol,1997,159(11):5187-5191.

引证文献1

广东医学
2005年 第9期

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