卵巢浆液性肿瘤中的血管生成研究

Angiogenesis in Serous Ovarian Neoplasms

目的检测卵巢浆液性肿瘤组织中的血管生成状况。方法采用免疫组化方法检测76例卵巢浆液性肿瘤组织中微血管密度(MVD)并分析其与主要临床病理参数及卵巢癌患者预后的关系。结果在良性、交界性及恶性浆液性卵巢肿瘤组织中MVD值呈逐渐增高趋势,三者之间差异均有显著性;浆液性卵巢癌不同的组织学分级中MVD差异有显著性,分化愈差,MVD值愈高;浆液性卵巢癌不同的FIGO分期中MVD差异有显著性,期别愈晚,MVD值愈高。浆液性卵巢癌组织中MVD值与患者预后有关,微血管密度高者预后差。结论血管生成在浆液性卵巢肿瘤的发生、发展中起重要促进作用,微血管密度值对预测患者预后有一定价值。

Objective To examine the angiogenesis in ovarian serous neoplasms.Methodsmethod was used to examine mieroveasel density （MVD） in 76 cases of serous ovarian neoplasms, and we also investigated MVD of the various histopathologie parameters and investigated the relationship between MVD and the total survival.Results Compared with eystadenomas, the fiasual MVD was signitlcanfly higher in borderline cystadenomas, but signitlcandy lower than cystadenocarcinomas.In serous ovarian carcinoma, the worse of tissual differentiated, the higher of MVD, the difference was significant.There was a signitlcandy higher MVD in the advance carcinomas than the earlier ones.The relationship was defined between MVD and prognosis. Conclusions Angiogenesis is very important in the carcinogenesis and developmentd serous ovarian neoplasams and MVD seems to be valuable prognostic indicator in serous ovarian cystadenocarcinomas.