胰岛B细胞功能、胰岛素抵抗判别的再论证

Re-demonstration of the Function of Pancreas B-cell and Judgment of Insulin Resistance

目的正确、科学地评估胰岛 B 细胞功能、胰岛素抵抗度,是评价治疗NIDDM新药疗效及毒副作用的基础。结果论证了OGTT试验按kg体重、计算服糖总量和采用变化度描述负荷试验相关指标的合理性,科学性。结论糖负荷后2h,3h 血糖水平,可作为评估胰岛素抵抗度的定量指标;胰岛素,C 肽峰值,次峰值所处的时点及其浓度,可作为评估胰岛B细胞负荷度,胰岛素合成速度的定量指标。(Gt)/(Go)·(It)/(Io)·(Co)/(Ct)可用于胰岛素抵抗的判别。

Aims Appraising tightly the function of pancreas B- cell and the extent of insulin resistance is the basis to evaluate new medical drugs effect and toxin and side effect that treat NIDDM. Results To demonstrate OGTT＇s test to count the gross amount of glucose taken by body weight and to describe the rationality and science quality of related index of charge experiment by varying Multiple of, Gt/Go·It/Io and Co/Ct.Conclusion The blood sugar level two or three hours after sugar charge is viewed as quantity index to appraise the extent of insulin resistance;the time point and concentration that the crest value and hypo- crest value of insulin and C - peptide are distributed are used as quantity index to appraise the charge extent of pancreas B- cell and synthesizing speed of insulin. Gt/Go·It/Io and Co/Ct is used as judgment of insulin resistance.