麻风固定疗程联合化疗后复发病例的分析

Analysis on the leprosy relapse after fixed treatment course of MDT

目的:评价麻风固定疗程联合化疗(FDMDT)后的远期复发率。方法:MB方案疗程24个月,PB方案疗程6个月,停药后定期随访患者的临床、病理、细菌变化,以观察FDMDT远期复发率。结果:4836例麻风患者采用FDMDT方案治疗,完成治疗4310例,其中MB方案3257例,复发12例,累积复发率为6.80/1000,平均复发潜伏期101.9个月;PB方案完成治疗1053例,复发2例,累积复发率为2.38/1000,平均复发潜伏期102.5个月。结论:凉山州、攀枝花两地20县FDMDT后复发率是低的,结果显示该方案疗程短、安全、疗效好,在边远山区和少数民族地区切实可行。

Objective： To evaluate the late relapse rate after fixed treatment course of MDT （FD - MDT） in leprosy patients. Methods： Muhibacillary （MB） leprosy patients were treated with a FD- MDT for 24 months, while paucibacillary （PB） leprosy patients were treated for 6 months. The clinical, pathological and bacteriological data were collected periodically after the treatment in order to observe the late relapse rate. Results： Among the 4 836 leprosy patients who received FD- MDT, 4 310 patients completed the treatment course, including 3 257 treated with the MB regimen, 12 patients relapsed with a accumulative rate of 6.80/1 000. The average latent period was 101.9 months. Among 1 053 patients who received PB regiment, 2 cases relapsed with an accumulative relapse rate of 2.38/1 000. The average latent period was 102.5 months. Conclusion： The relapse rate of leprosy after FD-MDT in 20 counties of Liangshan, Panzhihua prefecture is low. This kind of therapy has short duration, safety, and good results. It is feasible to carry out this therapy in remote mountainous and minority areas.