摘要
目的:研究2型糖尿病患者应用盐酸二甲双胍片(商品名:格华止)治疗后血压及体重指数(BMI)的变化。方法:选择56例2型糖尿病患者(合并高血压28例,正常血压者28例),应用格华止500mg,每日3次,治疗8周,治疗前后分别测定患者的空腹血糖(FBG)、餐后2h血糖(PBG)、收缩压(SBP)、舒张压(DBP)、BMI等指标,治疗后采用配对t检验。结果:治疗后患者的SBP、DBP、FBG、PBG均有显著下降,差别有统计学意义(P<0.05),BMI亦有下降,但无统计学意义(P>0.05)。结论:格华止对2型糖尿病患者除有降糖作用外,也有降压作用,考虑与胰岛素抵抗的改善有关。
Obiective :To investigate the effects of metformin on blood pressure and BMI in patient with type 2 diabetes. Methods :Fifty-six type 2 diabets received orally metformin(500 mg ,tid) for eight weeks. FBG ,PBG ,SBP ,DBP and BMI were measured before and after trail. Results :FBG,PBG,SBP,DBP were decreased significantly after treatment (P〈0.05). There was not significant difference about diffence about BMI before and after treatment. Conclusion:Metformin can lower level of blood glucose and decrease BP as well,so we think it is due to the improvement of insulin resistance.
出处
《临床医药实践》
2005年第8期581-582,共2页
Proceeding of Clinical Medicine