解脲支原体感染与男性不育

UREAPLASMA UREALYTICUM INFECTION AND MALE INFERTILITY

用双抗体夹心ＥＬＩＳＡ法检测解脲支原体，并与经典的培养法作了比较。３９例生育男性精浆解脲支原体ＥＬＩＳＡ法和培养法的阳性率分别为１０．３％和７．７％，１６４例不育者精浆解脲支原体两法阳性率分别为３５．４％和３１．７％，生育者与不育者解脲支原体阳性率差异非常显著（Ｐ＜０．００５）；ＥＬＩＳＡ法与培养法符合率为８６．５％。精子畸形率超过３０％及精子密度偏低（＜０．２亿／ｍｌ）的不育者，解脲支原体阳性率分别高达６９．２％和５６．５％。解脲支原体感染可导致精子形态与功能的异常，从而引起男性不育。

Double- antibody sandwich ELISA was used for the detection of ureaplasma urealyticum,and was compared with classical culture method. The positive rates were l0.3% by ELISA and 7.7% byclaseical culture respectively in the seminal plasma of 39 fertile men, while they were 35.4% and 31.7% respectively in the seminal plasma of 164 infertile men, From these results, we found the difference ofpositive rates was significant in fertile and infertile rnen, and their identity rate was 86.5% 。 The positiverates of ureaplasma urealyticum were 69.2% and 56.5% respectively in the infertile men with their spermmorphological abnormality over 30% , and in those with their sperm density lower than 20 million/ ml.Ureaplasma urealyticum infection may lead to male infertility due to the morphological and functional ab-normalities of sperm caused by it。