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IRS-2G1057D突变与2型糖尿病 被引量：1

IRS-2G1057D mutation and type 2 diabetes mellitus
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摘要 胰岛素受体底物(IRS)-2分子1995年由ARAKI等成功克隆。作为细胞质中的适配蛋白,IRS-2主要连接胰岛素受体和含SH2区蛋白,介导胰岛素(INS)、胰岛素样生长因子(IGF)-1等信号通道,调节细胞新陈代谢、生长和分化,是INS信号胞内传导的重要分子。人类IRS-2基因定位于13q8.6,有两个外显子和一个内含子,黄体酮可增强其转录,TZD(PPARγ激动剂)能快捷明显地增加其表达。IRS-2-/-动物具有2型糖尿病(T2DM)的全部特征,IRS-2基因突变可能参与人类T2DM的发生。 Insulin receptor substrate （IRS）-2 molecule was successfully cloned by Araki and others in 1995. As a linker protein in cytoplasm, IRS-2 is an important molecule of INS signal intraeellular conduction with main functions of to connect insulin receptor to the proteins with SH2 area, to communicate the signal conduction passages of insulin （INS） and insulin-like growth factor （IGF）-1 and to regulate cell metabolism, growth and differentiation. Human IRS-2 gene is located at 13q8.6 with two exons and an intron. Progesterone can increase its transcription. TZD （PRARγ agonist） can quickly and markedly enhance its expression. IRS-2^-/- animals bear all characteristics of type 2 diabetes meUitus （T2DM）. IRS-2 gene mutation may participate in the occurrence of human T2DM.
作者 孔令芳 钱聪 刘国良
机构地区 中国医科大学附属第一医院内分泌科 中国医科大学公共卫生学院流行病学教研室
出处 《中国现代医学杂志》 CAS CSCD 北大核心 2005年第15期2305-2307,共3页 China Journal of Modern Medicine
基金 辽宁省科技厅重点科技攻关基金资助项目(2001225001-16)
关键词 胰岛素受体底物-2 2型糖尿病 胰岛素抵抗 Insulin receptor substrate-2 Type 2 diabetes mellitus Insulin resistance
分类号 R587.1 [医药卫生—内分泌]
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共引文献2

同被引文献10

  • 1姜涛,宋秀霞,张敏,齐伟宏,张晓为.2型糖尿病胰岛素抵抗和胆固醇酯转运蛋白基因多态性的关联研究[J].中华医学遗传学杂志,2005,22(3):298-301. 被引量：7
  • 2惠宗光,周学伟,王晓玲,曹卫华,陈丽.2型糖尿病人群胰岛素抵抗和β_3-AR基因的相关性[J].潍坊医学院学报,2005,27(3):173-175. 被引量：3
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中国现代医学杂志
2005年 第15期

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