血浆降钙素基因相关肽含量的变化与妊娠

PLASMA CALCITONIN GENE-RELATED PEPTIDE LEVELS AND PREGNANCY

随机选择５２例好高征患者，２０名健康未孕妇女，３０例正常妊娠妇女用放射免疫测定法测定血浆降钙素基因相关肽（ＣＧＲＰ）水平。结果表明：妊娠组与未孕组之间ＣＧＲＰ含量差异显著（Ｐ＜０．０１）；妊高征组血浆ＣＧＲＰ显著高于妊娠组（Ｐ＜０．０１），提示：妊娠期高水平的ＣＧＲＰ是孕期血容量和红细胞升高反应的代偿机制。妊高征患者血浆ＣＧＲＰ含量增高可能与血管内皮系统的适应性和代偿性变化有关。但在重症好高征特别是子痫时血浆水平则明显下降。因此，血浆ＣＧＲＰ水平变化可能是诊断妊高征的一个指标。

Calcitonin gene-related peptide contents were determined in 52 pregnant women with preg- nancy induced hypertension (PIH ), 20 healthy non- pregnant and women, and 30 normal pregnant wome, There was significant difference of calcitonin gene- related peptide levels between non- pregnatnt and nor- mal pregnatnt women (P < 0. 0l ), while calcitonin gene- relaced peptide value in PIH was significantly higher than in normal grarid womenn (P< 0; 01 ). The level was positively correlated with the severity of PIH。 The results suggest that high levels in PIH maybe related to adaptive and compensatory changes in vascular endothelial system。 Plasma calcitonin gene- related peptide concentration could be used as a reli- able indicator of the saveritv of PIH。