小剂量索他洛尔与普罗帕酮治疗心律失常的疗效比较

Comparison of effects of low dose sotalol and propafenone on arrhythmias

目的比较小剂量索他洛尔与普罗帕酮治疗心律失常的疗效。方法收集心律失常患者78例,随机分为索他洛尔(S)与普罗帕酮(P)两组,S的用法为40,80,120mg/d,每2d递加,P的用量为450mg/d,治疗2周后做24h动态心电图判定疗效。结果室性早搏组40例次,S组22例,总有效率为77.3%;P组18例,总有效率为72.2%。二者之间无统计学差异(P=1.000)。室上性早搏(SV)组38例次,S组20例,总有效率为70.0%;P组18例,总有效率为66.7%。二者之间无统计学差异(P=0.731)。结论小剂量索他洛尔抑制室性早搏、室上性早搏的疗效与传统药物普罗帕酮相同。

Objective To compare the effect of low dose sotalol（S） and propafenone（P） on arrhythmia and their safety. Methods There were 78 patients with arrhythmia （ventricular V, n = 40, supraventricular arrhythmias SV, n = 38）, divided randomly into S and P groups. S group was given 40 mg/d and then increased 40 mg/d per 2 days. Propafenone was given 450 mg/d. After 2 weeks, the patients were evaluated by 24-hour ambulatory Holter. Results V group： sotalol effective rate was 77.3 % and propafenone effeetive rate was 70.0 % （ P 〉 0.05 between both） ; SV group： sotalol effective rate was 72.2 % and propfenone effective rate was 66.7 %（P 〉0.05）. Conclusion Low dose sotalol and propafenone are equally effective and safe for preventing the premature ventricular beats and premature supraventricular beats.