RVVC患者与VVC患者的流行病学研究

An Epidemic Investigation on Vulvovaginal Candidiasis (VVC) and Recurrence Vulvovaginal Candidiasis (RVVC) Patients

目的了解中国妇科/计划生育门诊中外阴阴道念珠菌病(VVC)及复发性VVC(RVVC)的发病情况及两者发病相关因素、既往用药和本次用药治疗的比较。方法对全国14家医院妇产科同天就诊的3590名患者进行阴道分泌物真菌学镜检,对VVC患者及RVVC患者进行调查登记和分析。结果(1)3590名患者当中,VVC、RVVC的发病率分别为11.60%和0.58%。(2)RVVC患者与普通VVC患者相比,在卫生习惯或应用激素、抗生素、避孕药、激素替代治疗等方面均无明显的特殊性,它的发生可能与局部的免疫异常有一定关系。(3)在既往的用药中,RVVC患者与普通VVC患者在应用局部药物方面无明显差异,但使用口服抗真菌药的几率要高于普通VVC患者。结论VVC尤其是RVVC对妇女身心健康有很大影响。RVVC的发生可能与局部的免疫异常有一定关系,应该对RVVC的患者尽可能选用敏感的抗真菌药物治疗,并一定要长疗程巩固治疗。

Objective To investigate the epidemic situation of vulvovaginal candidiasis （VVC） and recurrence vulvovaginal candidiasis （RVVC） among patients in gynecologic and birth control out - patient clinic, and to contrast the factors related to the incidence of VVC and RVVC, the drugs used and being used between the two groups. Methods Vaginal samples of all the patients going to gynecologic and birth control out - patients clinic in 14 hospitals on July 15th 2004 were examined by mycology. The patients with positive result, including VVC and RVVC patients were registered. Results （ 1 ） Among 3590 patients,the incidence of VVC and RVVC is 11.2% and 0. 58%. （2） There is no significant difference in the aspects of healthy habit,applying hornone or antibiotic, OC or HRT between the patients with VVC and RVVC. The incidence of RVVC is probably related to the local immunodefficiency. （3） There is no significant difference in local drugs used in the past between the patients with VVC and RVVC. But the rate of using oral antifungal in RVVC patients is higher than the rate in VVC. Conclusion Women＇s mental and physical health were influenced by VVC, especially by RVVC. The incidence of RVVC is probably related to the local immnnodefficiency. Patents with RVVC should be treated with sensitive antifungal and long- term strengthening treatment.