重庆地区261例发热待查病人嗜肺军团菌感染研究

A STUDY ON INFECTION OF LP1 IN PATIENTS WITH FEVER

本文报告了１９９０年１１月～１９９１年１１月重庆地区２６１例发热待查病人嗜肺军团菌Ⅰ型（ＬｅｇｉｏｎｌｉａｐｕｅｕｍｏｐｈｉｌａＬＰ１）感染研究。作者采用ＥＬＩＳＡ法测定其血清抗体效价水平。结果表明，血清抗休效价阳性有９５例，占总例数的３６％。其中抗体效价＜１：４０有６７例（７０．５％），＞１：８０有１６例（１６．８％），＞１：３２０有１２例（１２．６％）。在１２人达到诊断标准（１：３２０）的病人中，有９人年龄在５０岁以上、３人在５０发以下。还用直接荧光免疫法对１９例患者痰及支气管灌洗液作了ＬＰ１型抗原测定。结果表明，２名患者支气管灌洗液ＬＰ１抗原阳性。１名患者痰抗原阳性。本研究为临床军团菌感染的诊断和治疗提供了可靠依据。

n this study,261 patients with fever were tested for their antibody to Legionlia pneumophila I,(LP1 ) with enzyme-link immunosorbent assay(ELISA)。The results showed that 36%(95/261) were found positive reac-tion,in which the antibody titer was lower than 40 in 67 patients(70.5%),between 80 to 320 in 16 patients and more than 320 in only 12 patients sothat reached the diagnostic standard of infection of LP1.In the 12 patientsonly 3 of them were less than 50 years old.In addition,the sputa or per-fusate of lung were detected by direct fluorescent assay. The resuIts sugges- ted that 3 patients were found positive reaction,one from the sputum,andtwo from the perfusate.