摘要
甲基汞具有很强的神经毒性,可引起中枢神经系统不可逆改变,发育中的脑对甲基汞尤为敏感。本文就胎儿期、哺乳期低剂量甲基汞暴露对脑发育的影响及其性别差异,甲基汞的神经毒性机制等方面进行综述。
出处
《中国儿童保健杂志》
CAS
2005年第4期339-341,共3页
Chinese Journal of Child Health Care
基金
上海市教育委员会科研项目(04BB16)
参考文献16
-
1RAMIREZ GB, VINCE CRUZ MC, PAGULAYAN O, et al.The treatment and analysis and clinical correlates of mercury in maternal blood, breast milk, meconium, and infant's hair[J].JAMA, 2000, 106: 774-781.
-
2CRUMP KS, VAN LANDINGHAM C, SHAMLAYE C, et al. Benchmark concentrations for methlmercury obtained from the seychelles child development study[J]. Envron Health Perspect, 2000, 108: 257-263.
-
3KAKITA A, WAKABAYASHI K, SU M, et al. Intrauterine methylmercury intoxication consequence of the inherent brain lesions and cognitive dysfunction in maturity[J]. Brain Res,2000, 877: 322-330.
-
4SAKAMOTO M, KAKITA A, WAKABAYASHI K, et al. Evaluation of changes in methylmercury accumulation in the developing rat brain and its effects: a study with consecutive and moderate dose exposure through gestation and lactation periods[J]. Brain Res, 2002, 949: 51-59.
-
5ODDY WH. Breastfceding protects against illness and infection in infants and children[J]. Breastfeed Rev, 2001, 9:11-18.
-
6GOULET S, DORE FY, MIRAULT ME. Neurobehavioral changes in mice chronically exposed to methylmercury during fetal and early postnatal development[J]. Neurotoxicology and Teratology, 2003, 25:335-347.
-
7NISHIOKU N, TAKAI K, MIYAMOTO K, et al. Involvement of caspase-3-like and lysosomal proteases in methylmercury-induced apoptosis of primary cultured rat cerebral microglia[J]. Brain Res, 2000, 871:160-164.
-
8MOHN AR, GAINETDINOV RR, CARON MG, et al. Mice with reduced NMDA receptor expression display behaviors related to schizophrenia[J]. Cell, 1999, 98: 427-436.
-
9MIYAMOTO K, NAKANISHI H, MORIGUCHI S, et al. Involvement of enhanced sensitivity of N-methyl-D-asparate receptors in vulnerability of developing cortical neurons to methylmercury neurotoxicity[J]. Brain Res, 2001, 901: 252-258.
-
10ZANOLI P, CANNAZZA G, BARALDI M. Prenatal exposure to methylmercury in rats:focus on changes in kynurenine pathway[J]. Brain Res Bull, 2001, 55: 235-238.
同被引文献32
-
1钱浩骏,叶细标,傅华.汞及其化合物的慢性神经毒性[J].环境与职业医学,2005,22(2):160-162. 被引量:8
-
2周思朗,屈艳妮,张健,汪森明,张积仁.SRB法与MTT法细胞计数应用比较[J].中国现代医学杂志,2005,15(17):2615-2617. 被引量:29
-
3FLOREA A M, BUSSELBERG D. Occurrence, use and potential toxic effects of metals and metal compounds [ J ]. Biometals, 2006,19 (4) : 419 - 427.
-
4BERMAN R F, PESSAH I N, MOUTON P R, et al. Low-level neonatal thimerosal exposure:further evaluation of altered neurotoxic potential in SJL mice[ J]. Toxicol Sci ,2008,101 (2) :294- 309.
-
5MCCABE M J J R,LAIOSA M D,LI L,et al. Low and nontoxicinorganic mercury burdens attenuate BCR-mcdiated signal transduction [J]. Toxicol Sci,2007,99(2) :512 -521.
-
6LIU J,SHI J Z,YU L M ,et al. Mercury in traditional medicines:is cinnabar toxicologically similar to common mercurials? [ J ]. Exp Biol Med (Maywood) ,2008,233 (7) :810 - 817.
-
7NEWLAND M C, PALETZ E M, REED M N, et al. Methylmercury and nutrition:adult effects of fetal exposure in experimental models [ J]. Neurotoxicology,2009,30( 1 ) :161 - 163.
-
8SOARES F A, FARINA M, SANTOS F W, et al. Interaction between metals and chelating agents affects glutamate binding onbrain synaptic membranes[ J]. Neurochem Res ,2003,28 (12) : 1859 - 1865.
-
9SEGURA A J, KOSTRZEWA R M. Neurotoxins and neurotoxic species implicated in neurodegeneration [ J ]. Neumtox Res, 2004,6 ( 7/8 ) : 615 -630.
-
10NASCIMENTO J L M,OLIVEIRA K R,CRESPO-LOPEZ M E,et al. Methylmercury neurotoxieity & antioxidant defenses[ J]. Indian J Med Res,2008,128 (10) :373 -382.
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-
1徐珍,张玉芹,彭芳.汞神经毒性机制研究进展[J].中国职业医学,2010,37(6):503-504. 被引量:3
-
2夏政华,李岑,毕宏涛,耿卢婧,杜玉枝,魏立新.藏药佐太和甲基汞对神经细胞Neuro-2a毒性的差异比较[J].甘肃农业大学学报,2021,56(1):29-36. 被引量:1
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-
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-
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-
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-
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-
1高宇,沈晓明.甲基汞与母亲孕期食鱼对儿童健康的影响[J].中国儿童保健杂志,2002,10(4):257-259. 被引量:4
-
2杨建明,蒋学之,王簃兰.汞的胎盘转运及乳汁传递[J].环境与职业医学,1992,16(2):61-61.
-
3陈西平,王成斌.软骨藻酸和谷氨酸受体[J].卫生研究,2000,29(4):255-256. 被引量:2
-
4张素华,张兆志.一氧化氮的神经毒性机制[J].职业与健康,2004,20(3):10-10. 被引量:1
-
5王贤裕,田玉科.小剂量氯胺酮镇痛的临床研究进展[J].国外医学(麻醉学与复苏分册),2004,25(5):295-298. 被引量:39
-
6李乐慧,徐兆发,刘巍,奉姝,杨天瑶,李静慧.牛磺酸对甲基汞致大鼠脑氧化损伤的保护作用[J].环境与职业医学,2014,31(6):469-471. 被引量:7
-
7刘爱勤,岳秀英.小剂量氯胺酮和咪唑安定用于人工流产术疗效评价[J].青岛医药卫生,2003,35(6):418-418.
-
8冯雅珍,袁彤,冯艳华,麻海春.小剂量氯胺酮对小儿术后镇痛中舒芬太尼作用的影响[J].中国妇幼保健,2011,26(31):4959-4959. 被引量:5
-
9张彦文,余争平,谢燕,方强,张广斌.微波辐照对大鼠海马NMDA受体NR_1和NR_(2B)亚基基因及蛋白表达的影响[J].解放军预防医学杂志,2007,25(3):167-170. 被引量:6
-
10丁宏伟,李岩.锰的神经毒性机制研究进展[J].实用预防医学,2016,23(8):1022-1024. 被引量:15