白细胞介素23研究进展被引量：5

Progress in IL-23 research

下载PDF

导出

摘要白细胞介素23(IL-23)是新近发现的一种异二聚体细胞因子,由p19和IL-12的p40亚单位组成,系IL-12家族成员。它主要由活化的树突细胞和巨噬细胞分泌,IL-12Rβ1和IL-23R为其受体。IL-23能促进T细胞的增殖及IFN-γ的产生,具有较强的抗肿瘤活性和抗感染免疫保护功能。

作者吴茜茜卢洁潘建平

机构地区浙江大学免疫学研究所浙江省台州医院中心实验室

出处《国外医学（流行病学．传染病学分册）》 2005年第4期236-239,共4页 Epidemiology Lemology Foreign Medical Sciences

关键词细胞因子 IL-23 分子结构生物学功能白细胞介素23 IL-12 免疫保护功能抗肿瘤活性异二聚体家族成员

分类号 R392 [医药卫生—免疫学]

引文网络
相关文献

参考文献18

1Oppmann B, Lesley R, Blom B, et al. Novel p19 protein engages IL-12p40 to form a cytokine, IL-23, with biological activities similar as well as distinct from IL-12. Immunity, 2000,13 (5): 715-725.
2Smits HH, van Beelen A J, Hessle C, et al. Commensal Gram-negative bacteria prime human dendritic cells for enhanced IL-23 and IL-27expression and enhanced Th1 development. J Immunol, 2004, 34 (5):1371-1380.
3Morelli AE, Zahorchak AF, Larregina AT, et al. Cytokine production by mouse myeloid dendritic cells in relation to differentiation and terminal maturation induced by lipopolysaccharide or CD40 ligation. Blood,2001, 98(5): 1512-1523.
4Frucht DM. IL-23: A cytokine that acts on memory T cells. Sci Stke,2002, 2002(114): 1-3.
5Parham C, Chirica M, Timans J, et al. A receptor for the heterodimeric cytokine IL-23 is composed of IL-12Rβ1 and a novel cytokine receptor subunit, IL-23R. J Immunol, 2002,168 (11): 5699-5708.
6Belladonna ML, Renauld JC, Bianchi R, et al. IL-23 and IL-12 have overlapping, but distinct, effects on murine dendritic cells. J Immunol,2002,168 (11): 5448-5454.
7Lo CH, Lee SC, Wu PY, et al. Antitumor and antimetastatic activity of IL-23. J Immunol, 2003, 171 (2): 600-607.
8Wang YQ, Ugai S, Shimozato O, et al. Induction of systemic immunity by expression of interleukin-23 in murine colon carcinoma cells. J Cancer, 2003,105 (6): 820-824.
9Ugai S, Shimozato O, Yu L, et al. Transduction of the IL-21 and IL-23 genes in human pancreatic carcinoma cells produces natural killer celldependent and -independent antitumor effects. Cancer Gene Ther, 2003.(10): 771-778.
10Leonard JP, Sherman ML, Fisher GL, etal. Effects of single-dose interleukin-12 exposure on interleukin-12-associatad toxicity and interferonγ production. Blood, 1997, 90 (7): 2541-2548.

同被引文献42

1中华妇产科学分会感染性疾病协作组.外阴阴道念珠菌病诊治规范(草案)[J].中华妇产科杂志,2004,39(6):430-431. 被引量：490
2赵敬军,童华,张正华,刘维达.念珠菌性外阴阴道炎患者阴道分泌物中白介素4和白介素12水平测定[J].中华皮肤科杂志,2005,38(3):178-179. 被引量：8
3李家文,曹菲,谭志建,丁娟,张德美,邬炎卿,曾敬思.系统性白念珠菌感染小鼠IL-12和IL-23的表达[J].中国麻风皮肤病杂志,2006,22(4):270-273. 被引量：2
4刘菲,廖秦平.外阴阴道念珠菌病致病机制和免疫防御机制的研究进展[J].中国妇产科临床杂志,2006,7(3):227-228. 被引量：21
5谭广,王忠裕.白细胞介素-23的研究进展[J].国际检验医学杂志,2006,27(10):894-895. 被引量：2
6Sobel JD. Vulvovaginal eandidosis [ J ]. Lancet, 2007, 369 (9577) : 1961 - 1971.
7Cassone A, De Bernardis F, Santoni G. Anti candidat immunity and vaginitis: novel opportunities for immune intervention [ J]. Infect Immun, 2007, 75(10):4675-4686.
8Fidel PLJr, Luo W, Steele C, et al. Analysis of vaginal cell populations during experimental vaginal candidiasis [ J ]. Infect Immun, 1999, 67(8) :3135 -3140.
9Kobayashi M, Fitz L, Ryan M, et al. Identification and purification of natural killer cell stimulatory factor( NKSF), a cytokine with multiple biologic effects on human lymphocytes [ J ]. Exp Med, 1989,170 ( 3 ) : 827 - 844.
10Romani L, Puccetti P, Bistoni F. Interleukin-12 in infections diseases [J]. Clin Microbiol Rev, 1997, 10(4) :611 -636.