2型糖尿病患者动态血压变化分析

Changes and analysis of ambulatory blood pressure in type 2 DM

目的了解2型糖尿病患者的动态血压变化。方法对32例单纯2型糖尿病患者(A组),30例2型糖尿病合并高血压患者(B组),36例非糖尿病高血压患者(C组)及30例正常对照人群(D组)进行24小时动态血压监测,比较其数据。结果A组、B组及C组的昼夜平均动脉压差值明显低于D组(P<0.01),尤以B组为甚。B组昼夜平均动脉压差值也明显低于C组(P<0.05)。结论糖尿病组失去正常血压昼夜节律,并且这种异常在出现高血压之前已经存在,提示该异常的产生机制有别于非糖尿病患者。对糖尿病患者定期进行动态血压监测有助于早期发现血压异常,甚至在患者仅出现血压昼夜节律异常时即进行干预,阻止或延缓其进一步发展,从而有助于糖尿病并发症的防治。

Objective To study the changes of ambulatory blood pressure （ABP） in type 2 DM. Methods To monitor the ABP of 32 cases with type 2 DM （group A）, 30 eases with hypertension and DM （group B）, 36 cases with primary hypertensive （group C） and 30 cases of normal people （group D）, then compare and analyze the differences among the data. Results The group A, group B and group C had blunted noctrunal BP reduction than the group D （P〈0. 01）, especially the group B. The group B also had blunted nocturnal BP reduction the group C （P〈0.05） . Conclusion Diabetic groups with or without hypertension lose their normal diurnal BP rhythm, even at the time when they are still normotensive. This indicate that the pathophysiology of diabetic abnormal diumal BP rhythm is probably somewhat different from non-diabetes. Patients with diabetes should have ABP monitoring periodically, this will help to find the abnormal blood pressure, and treat the hypertension, even at the time of the abnormal diurnal BP rhythm. This will contribute to the prevention and treatment of the complications of patients with diabetes.