高压氧综合治疗对脑外伤后抑郁患者情感及认知功能的影响

Influence of Hyperbaric Oxygenation Comprehensive Rehabilitation on Emotion and Cognitive Function of the Patients with Post-traumatic Depression

目的:探讨高压氧治疗脑外伤后抑郁症患者的疗效。方法:脑外伤后抑郁患者68例随机分为高压氧组与常规组各34例。2组均接受常规营养脑血管和抗抑郁药物治疗;高压氧组同时增加高压氧治疗。结果:治疗3个疗程后,高压氧组汉密尔抑郁量表、简易精神状态检查表评分及听觉Oddball刺激序列P3检测结果与治疗前比较均有显著改善(P<0.05),与常规组比较差异亦有显著性意义(P<0.05);而常规组治疗前后相应指标比较差异无显著性意义。结论:高压氧可改善脑外伤后抑郁患者的抑郁状态,提高其情感及认知功能。

Objective： To study the effectiveness of hyperbaric oxygenation （HBO） in the treatment of the patients with depression following brain trauma. Methods： Sixty-eight cases of depression following brain trauma were randomly divided into 2 groups： control group undergoing anti-depression drugs therapy only, and HBO group receiving subject to HBO therapy besides anti-depression drugs therapy. Results： After comprehensive rehabilitation therapy, the assessment of HRSD, MMSE and P3 check were improved significantly in the HBO group as compared with those in the control group （P〈0.05）. There was no obvious difference in the control group before and after treatment. Conclusion： HBO comprehensive rehabilitation therapy is effective in the treatment of the patients with depression following brain trauma.