脊灰减毒活疫苗免疫强度对甲型肝炎报告发病率的影响

The Relationship between Incidence of Hepatitis A and Supplementary Immunology of Trivalent Oral Poliomylitis Vaccine

目的分析TOPV免疫强度与甲肝报告发病率变化的关系和内在联系。方法数据来自西安市1989-2003年疫情年报资料,应用χ2、rs、RR等方法处理数据。结果自1993年实施TOPV强化免疫后甲肝发病呈明显下降趋势(I=10,P<0.01),与TOPV免疫强度有明显的剂量-反应关系(rs=-1.000),但以扫荡式强化下降幅度最为显著(χ2=322.3736,P<0.001),经分组比较:年龄组下降以接种组(0～47月龄)最为显著(χ2=1217.6138,P<0.001),职业组下降以散居儿童最显著(χ2=340.8883,P<0.001);强化服苗后季节发病亦有显著变化(χ2=251.5852,P<0.001)。结论在西安市未实施甲肝疫苗普种出现发病率明显下降可能与1993年以来TOPV强化有关,其机制可能与肠道病毒间干扰作用有关。

Objective To investigate the epidemic trend of hepatitis A from 1989 to 2003, and its effective influence factors. Methods Epideroic surveillance data of Xi＇an from 1989 to 2003 was analysed. Results The incidence of hepatitis A was declined year by year, after supplementary immunology of TOPV was carried out （I = 10, P 〈 0.05） .There was significunt affection relationship between supplementary immunology and incidence of hepatitis A, especially in supplementary immnunologyical group, 0 - 47 months old （X^2 = 1217.6138, P 〈 0.001 ）. Conclusion The mechannism declined incidence of hepatitis A is probably due to inter ference action between intestinal virus and TOPV.