TGFβ1及TβRⅡ在子宫内膜癌组织中的表达及其临床意义

Expressions of TGFβ1 and TβR Ⅱ in human endometrial carcinoma and their clinical significance

目的研究转化生长因子β1(trans-forming growthfactorβ1,TGFβ1)及转化生长因子Ⅱ型受体(type II of transforminggrowth factorβreceptor,TβRⅡ)在子宫内膜癌组织中的作用及与其生物学行为的关系。方法采用SP免疫组化法检测57例子宫内膜癌和30例正常子宫内膜组织中TGFβ和TβRⅡ表达。结果TGFβ1与TβRⅡ在正常子宫内膜及内膜癌组织中均有表达,且TGFβ1与TβRⅡ两者表达呈一致性(P>0·05);TGFβ1与TβRⅡ的表达在子宫内膜癌组织中的表达显著高于正常内膜(P均<0·05);其表达与内膜癌的临床期别、浸润肌壁深度和淋巴结转移均呈负相关(P均<0·05),与分化程度则呈正相关(P<0·01)。结论TGFβ1及其受体在子宫内膜癌的发生发展中起重要作用,检测TGFβ1及其受体TβRⅡ对评价子宫内膜癌的转移及预后有重要价值。

OBJECTIVE： To investigate the role of transforming growth factor （TGF）β1 and type Ⅱ of transforming growth factor β receptor （TβR Ⅱ ） in endometrial carcinoma and their correlation with the behavior of endometrial carcinoma. METHODS： TGFβ1 and TβRⅡ were measured in endometrial carcinoma （57 cases） and normal endometrium （30 cases） by SP immunohistochemical method. RESULTS： The expressions of TGFβ1 and TβR Ⅱ were detected in normal endometrium and endometrial carcinoma, but there was no significant difference （P〉0.05）. The expression of TGFβ1 and TβR Ⅱ in endometrial carcinoma showed significantly higher than those in normal endometrium （P〈0.05）. The expressions of TGFβ1 and TβR Ⅱ in endometrial carcinoma had negative relation to the clinical stage, depth of myometrial invasion, lymphonode metastasis （P〈0.05） and positive relation to the differential grading （P〈0.01）. CONCLUSIONS： TGFβ1 and TβRⅡ play an important role in pathogenesis and development of endometial carcinoma. Detecting the expression of TGFβ1 and TβRⅡ in endometrial carcinoma has an important value in evaluating the metastasis and prognosis of endometrial carcinoma.