局部复发鼻咽癌超分割加立体定向适形放疗的临床研究

Results of hyperfractionated radiotherapy followed by 3D conformal radiation therapy boost to recurrent nasopharyngeal carcinoma

目的:初步评价超分割外照射加立体定 向适形放射剂量治疗局部复发鼻咽癌的临床疗 效及毒副反应。方法:对1999～2002年收治的 14例复发鼻咽癌进行超分割外照射(1.3Gy/次, 2次/d,总剂量42～60Gy)加立体定向适形放射 推量(4Gy/次,隔日照射,共10次,总量20Gy) 的临床研究。结果:总有效率(CR+PR)85.7% (12/14),其中完全消退(CR)64.3%(9/14),部分 消退(PR)21.4%,肿瘤稳定14.3%,2年总生存 率57.1%(8/14),无瘤生存率42.8%(6/14),靶 区肿瘤控制率为78.6%(11/14)。结论:超分割 外照射加立体定向适形放射剂量治疗局部复发 鼻咽癌在临床上是可行及有效的。

OBJECTIVE： To evaluate the clinical value of hyperfractionated external irradiation followed by 3D conformal radiation therapy boost to recurrent NPC after primary radiotherapy. METHODS：From 1999 to 2002 14 patients with local recurrent were treated, receiving hyperfractionated external irradiation（1.3 Gy/fraction, twice daily, total dose 42 - 60 Gy） followed by 3D conformal radiation therapy boost （5 fractions/ 10 days,4 Gy/per fraction, and total dose 20 Gy）. RESULTS： The overall response rate was 85.7 % （12/14） and complete response was 64.3% （9/14）, and 2-year local control rate was 78.6% （11/14）,2-year survivals rate was 57. 1%（8/14）. CONCLUSION： Hyperfraction external radiotherapy followed by 3D conformal boost is an effective treatment for recurrent NPC.