摘要
目的:观察奥沙利铂(L OHP) 联合希罗达(Xeloda)在治疗晚期胃癌中 的作用。方法:L OHP130mg/m2,静脉 滴入,d1,Xeloda2500mg/m2,早晚各服 1次,连服14d,21d重复。结果:21例 患者中,CR1例,PR12例,NC5例,PD 3例,RR61.9%。毒副反应主要为外周 神经损害、手足综合征、恶心和呕吐,患 者均可耐受。结论:L OHP联合希罗达 方案治疗晚期胃癌具有较好的疗效,能 显著提高患者的生存质量。
OBJECTIVE： To evaluate the efficacy and adverse of Oxaliplation （L-OHP） plus Xeloda（eapeeitabine） in the treatment of advanced gastric carcinoma. METHODS： L-OHP was administered as a 2-hour infusion at a dose of 130 mg/m^2 on day 1 ;Xeloda treatment given at a dose of 2 500 mg/m^2 twice daily,on days 1～14 evrey 21 days. RESULTS：Twenty-one patients were evaluable for treament outcome. One obtained CR,12 PR,5 NC,3 PD.and the overall response rate was 61.9 %, The major toxicity and side effats were peripheral newropathy, hand-foot syndrome, nausea and vomiting, but they were acceptable. CONSLUSION：L-OHP plus Xeloda is a highly effective regimen for patient with advanced gastric carcinoma,with a manageable toxicity.
出处
《肿瘤防治杂志》
2005年第4期303-304,共2页
China Journal of Cancer Prevention and Treatment
