脑血流图在家兔眩晕造模中的应用

Application of Rheoencephalogram in Constructing Giddy Model of Rabbit

目的:通过观察家兔造模前后脑血流图的变化,探讨脑血流图在眩晕动物实验中的应用价值。方法:采用REG-IG2型血流图自动分析诊断仪,观察气虚血瘀型眩晕证大耳白兔造模前后的脑血流图变化。结果:(1)在模型组,造模后与造模前比,脑血流图波幅、S(面积)、V(速率)、F1(弹力指数)等指标均有所下降,Z1(阻力指数)增加,差异有显著性意义(P<0.05),说明造模后家兔脑血流量相对减少,血流速度变化变慢,血管紧张度增高,弹性下降,脑血管阻力增加。(2)模型组与正常组比较,模型组造模后脑血流图的波幅、S(面积)、V(速率)、F1(弹力指数)等指标均有所下降,Z1(阻力指数)增加,差异有显著性意义(P<0.05),说明模型组脑血流量相对减少,血流速度变化变慢,血管紧张度增高,弹性下降,脑血管阻力增加。结论:脑血流图检测可反映脑血管供血量和功能状况的变化,在眩晕动物实验中有较大的应用价值。

Objective： Through observing the change of rheoencephalogram of rabbits before and after constructing model, the paper explored value of rheoencephalogram in the experience. Method ： To adopt rheogram automatic analysis and diagnosis machine with type REG - IG2 for observing the change of rheoencephalogram of rabbits type of Qi deficiency and blood stasis before and after constructing model. Result： （ 1 ） at model group, comparing to before and after constructing model, we could find the amplitude, areas, speed rate, elasticity index and other targets were descended, resistant index added up, that＇s distinct difference, that also expounded that cerebral blood flow decreased after constructing model, the change of blood flow speed became slow, vascular tone became high, elasticity became low, the cerebral vascular resistance added up. （2） Compared model group with normal group, after constructing model, the amplitude, areas, speed rate, elasticity index and other rheoencephalogram targets were descended in the model group,resistant index added up, that＇s distinct difference, that also expounded that cerebral blood flow decreased at the model group, the change of blood flow speed became slow, vascular tone became high, elasticity became low, the cerebral vascular resistance added up.Conclusion ： the examination of rheoencephalogram can reflect the blood - supply quantity of cerebral vessel and functional change, so it has a great applicative value in animal experiment of giddy.