镇喘颗粒对支气管哮喘患者神经生长因子及嗜酸性粒细胞的影响

Effect of Antasthmatic Granules on NGF and EOS of Bronchial Asthma Patients

目的:观察镇喘颗粒对支气管哮喘患者外周血中神经生长因子NGF的表达及嗜酸粒细胞EOS计数的影响;方法:80例哮喘患者采用镇喘颗粒治疗,治疗前后均测定血液中NGF、EOS及肺功能,并以氨茶碱治疗40例作为对照;结果:治疗后两组患者血液中NGF、EOS均有改善,但治疗组较对照组效果更为明显(P<0.01),肺功能改善以MEF50%为明显,治疗组亦优于对照组。结论:镇喘颗粒能明显降低患者外周血中NGF的表达及嗜酸性粒细胞的计数,同时患者肺功能得到改善,提示药物能缓解支气管哮喘患者气道高反应状态。

Objective： To observe the effect of Antasthmatic Granules on NGF expression and EOS count in peripheral blood bronchial asthma（BA） patients. Method： 80 cases of BA patients were treated with Antasthmatic Granules. NGF, EOS and Lung function all were examined before and after treatment, and the authors created 40 cases treated with aminophylline as the control group to be compared. Result： After treatment, NGF and EOS all were improved in two groups, but the treatment groups was more obvious than control group（P 〈 0.01 ）. Lung function improvement used MEF50% as the distinct target, the treatment group was also better. Conclusion： Antasthmatic Granules can decrease the on NGF expression and EOS count in peripheral blood, and improve the lung function. So it indicates the drugs can relieve airway high - reaction state of BA patients.