肝细胞癌中泛素蛋白表达及其与临床病理学的相关性

A study on the ubiquitin expression and its clinicopathologic significance in hepatocellular carcinoma

目的探讨肝细胞癌中泛素蛋白表达及其临床病理学意义。方法应用免疫组化方法在组织微阵列上检测泛素蛋白表达,并分析其与临床病理学指标之间相关性。结果肝细胞癌中泛素蛋白表达明显增强,并与肿瘤分级、分型、乙型肝炎病毒感染密切相关(P分别<0.05,0.01和0.05),与患者性别、年龄、肿瘤大小、癌旁状况、AFP水平等指标无相关性(P>0.05)。结论蛋白酶体功能增强是肝细胞癌发生、发展的重要机制,检测肿瘤中泛素蛋白表达可用于指导临床治疗。

Objective To explore the expression status of ubiquitin in hepatocellular carcinoma and its clinicopathologic significance.Method Ubiquitin was detected in tissue microarray by immunohistochemistry,in addition, the relativity between ubiquitin expression and clinicopathologic indexes was analyzed.Results Ubiquitin expression not only was remarkably enhanced in hepatocellular carcinoma, but also correlated with tumor grade, type and HBV infection （P〈0.05, 0.01, 0.05, respectively）. No relativity was found between ubiquitin expression and age, gender, tumor size, surrounding tissue, AFP level （P〉0.05）.Conclusion A important mechanism in hepatocellular carcinoma occurrence and development is the elevation of proteasome function. Ubiquitin detection would direct clinic therapy in the near future.